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2. Metformin - Wikipedia

   en.wikipedia.org/wiki/Metformin

   Metformin has acid dissociation constant values (pK a) of 2.8 and 11.5, so it exists very largely as the hydrophilic cationic species at physiological pH values. The metformin pK a values make it a stronger base than most other basic medications with less than 0.01% nonionized in blood.

3. Is There a "Best Time" to Take Metformin? - AOL

   www.aol.com/best-time-metformin-115700262.html

   Well, there’s no magic time, but you should take metformin at the same time each day and with food to avoid gastrointestinal side effects. If you’re taking extended-release metformin tablets ...

4. 6 Benefits of Taking Metformin (Besides Weight Loss) - AOL

   www.aol.com/lifestyle/6-benefits-taking...

   2. Alleviates Hunger. Metformin improves how well your cells respond to insulin. This helps regulate your blood sugar levels and manage spikes in insulin that can trigger hunger and food cravings.

5. Does Metformin Cause Diarrhea? Coping With Gut-Related Side ...

   www.aol.com/lifestyle/does-metformin-cause...

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6. Biguanide - Wikipedia

   en.wikipedia.org/wiki/Biguanide

   Kidney function should be assessed before starting metformin. Phenformin and buformin are more prone to cause acidosis than metformin; therefore they have been practically replaced by it. However, when metformin is combined with other drugs (combination therapy), hypoglycemia and other side effects are possible. [citation needed]

7. Sitagliptin - Wikipedia

   en.wikipedia.org/wiki/Sitagliptin

   Serious side effects may include angioedema, low blood sugar, kidney problems, pancreatitis, and joint pain. [8] Whether use in pregnancy or breastfeeding is safe is unclear. [ 10 ] It is in the dipeptidyl peptidase-4 (DPP-4) inhibitor class and works by increasing the production of insulin and decreasing the production of glucagon by the pancreas.

8. Alpha-glucosidase inhibitor - Wikipedia

   en.wikipedia.org/wiki/Alpha-glucosidase_inhibitor

   In the colon, bacteria will digest the complex carbohydrates, thereby causing gastrointestinal side effects such as flatulence and diarrhea. Since these effects are dose-related, it is generally advised to start with a low dose and gradually increase the dose to the desired amount. Pneumatosis cystoides intestinalis is another reported side ...

9. Vildagliptin/metformin - Wikipedia

   en.wikipedia.org/wiki/Vildagliptin/metformin

   Vildagliptin/metformin is indicated in the treatment of type-2 diabetes mellitus: [4] [6] [7] it is indicated in the treatment of adults who are unable to achieve sufficient glycaemic control at their maximally tolerated dose of oral metformin alone or who are already treated with the combination of vildagliptin and metformin as separate tablets.