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Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). [2] [8] Early on, there are typically no symptoms. [2] Later, non-painful lymph node swelling, feeling tired, fever, night sweats, or weight loss for no clear reason may occur.
Lymphoproliferative disorders are a set of disorders characterized by the abnormal proliferation of lymphocytes into a monoclonal lymphocytosis.The two major types of lymphocytes are B cells and T cells, which are derived from pluripotent hematopoietic stem cells in the bone marrow.
Hematologists base CLL treatment on both the stage and symptoms of the individual person. A large group of people with CLL have low-grade disease, which does not benefit from treatment. Individuals with CLL-related complications or more advanced disease often benefit from treatment. In general, the indications for treatment are:
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Symptoms can include swollen but painless lymph nodes, unexplained fever, and unintended weight loss. [2] There are several subtypes, the most common of which is follicular lymphoma. Others include cutaneous T-cell lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, and Waldenström macroglobulinemia. [2]
B-cell chronic lymphocytic leukemia (ICD-O: 9823/3) 30% of all leukemias. Also 3 to 4% of lymphomas in adults [1] Small resting lymphocytes mixed with variable number of large activated cells. Lymph nodes are diffusely effaced [1] CD5, surface immunoglobulin [1] Occurs in older adults. Usually involves lymph nodes, bone marrow and spleen.
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