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Domperidone, sold under the brand name Motilium among others, is a dopamine antagonist medication which is used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis (delayed gastric emptying). It raises the level of prolactin in the human body and is used off label to induce and promote breast milk production.
A galactagogue, or galactogogue (from Greek: γάλα [γαλακτ-], milk, + ἀγωγός, leading), also known as a lactation inducer or milk booster, is a substance that promotes lactation in humans and other animals. [1] [2] It may be synthetic, plant-derived, or endogenous. They may be used to induce lactation and to treat low milk supply.
Normal histology of the breast during lactation. Mammoplasia is the normal or spontaneous enlargement of human breasts. [1] Mammoplasia occurs normally during puberty and pregnancy in women, as well as during certain periods of the menstrual cycle. [2] [3] [4] When it occurs in males, it is called gynecomastia and is considered to be ...
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Medical conditions in the infant that result in weak or unco-ordinated sucking can cause low milk supply by inhibiting the transfer of milk to the baby. [6] These conditions include tongue-tie, [6] congenital heart defects, [6] prematurity, [6] and Down syndrome. [7] Primary causes of low milk supply include:
In humans, induced lactation and relactation have been observed frequently in some cultures, and demonstrated with varying success in adoptive mothers and wet nurses. [ 17 ] [ 18 ] It appears plausible that the possibility of lactation in women (or females of other species) who are not biological mothers does confer an evolutionary advantage ...
Whereas D 2 receptor agonists suppress prolactin secretion, dopamine D 2 receptor antagonists like domperidone and metoclopramide have the opposite effect, strongly inducing the pituitary secretion of prolactin, and are sometimes used as prolactin releasers, for instance to correct hypoprolactinemia (low prolactin levels) in the treatment of lactation failure. [2]
"Drug which has been taken by a large number of breastfeeding mothers without any observed increase in adverse effects in the infant. Controlled studies in breastfeeding women fail to demonstrate a risk to the infant and the possibility of harm to the breastfeeding infant is remote; or the product is not orally bioavailable in an infant."