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Postorgasmic illness syndrome (POIS) is a syndrome in which human males have chronic physical and cognitive symptoms following ejaculation. [1] The symptoms usually onset within seconds, minutes, or hours, and last for up to a week. [1] The cause and prevalence are unknown; [2] it is considered a rare disease. [3]
The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response. [19]
The conformation of the alpha-synuclein is different from that of alpha-synuclein in Lewy bodies. [3] The disease probably starts with an oligodendrogliopathy. [ 34 ] It has been proposed that the α-synuclein inclusions found in Oligodendrocytes result from the pruning and the engulfment of diseased axonal segments containing aggregated α ...
All symptoms normally resolve within three weeks, and may only last days. [1] Permanent deficits are seen in a minority of patients, ranging from under 10% to 20% in various studies. [ 1 ] Less than 5% of patients experience progressive vasoconstriction, which can lead to stroke, progressive cerebral edema , or even death. [ 1 ]
Individuals with exploding head syndrome hear or experience loud imagined noises as they are falling asleep or are waking up, have a strong, often frightened emotional reaction to the sound, and do not report significant pain; around 10% of people also experience visual disturbances like perceiving visual static, lightning, or flashes of light.
Neurodegeneration with brain iron accumulation is a heterogenous group of inherited neurodegenerative diseases, still under research, in which iron accumulates in the basal ganglia, either resulting in progressive dystonia, parkinsonism, spasticity, optic atrophy, retinal degeneration, neuropsychiatric, or diverse neurologic abnormalities. [1]
Enjoy a classic game of Hearts and watch out for the Queen of Spades!
[4] [6] [8] [11] Dr. Daniel LaChance, a physician at both the Austin Medical Center and the Mayo Clinic in nearby Rochester, Minnesota, was notified. He launched a request to area physicians to refer other patients with similar symptoms to him. [11] The Minnesota Department of Health was notified and began an investigation into the "outbreak."