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The study concludes that bacteriophage preparations were safe and effective for treatment of chronic ear infections in humans. Additionally, there have been numerous animal and other experimental clinical trials evaluating the efficacy of bacteriophages for various diseases, such as infected burns and wounds, and cystic fibrosis-associated lung ...
d'Hérelle was a self-taught microbiologist. In 1917 he discovered that "an invisible antagonist", when added to bacteria on agar, would produce areas of dead bacteria. The antagonist, now known to be a bacteriophage, could pass through a Chamberland filter. He accurately diluted a suspension of these viruses and discovered that the highest ...
The phi X 174 (or ΦX174) bacteriophage is a single-stranded DNA virus that infects Escherichia coli. This virus was isolated in 1935 by Nicolas Bulgakov [1] in Félix d'Hérelle's laboratory at the Pasteur Institute, from samples collected in Paris sewers. Its characterization and the study of its replication mechanism were carried out from ...
The first human virus to be identified was the yellow fever virus. [6] In 1881, Carlos Finlay (1833–1915), a Cuban physician, first conducted and published research that indicated that mosquitoes were carrying the cause of yellow fever, [ 7 ] a theory proved in 1900 by commission headed by Walter Reed (1851–1902).
In a 1945 study by Demerec and Fano, [4] T7 was used to describe one of the seven phage types (T1 to T7) that grow lytically on Escherichia coli. [5] Although all seven phages were numbered arbitrarily, phages with odd numbers, or T-odd phages, were later discovered to share morphological and biochemical features that distinguish them from T-even phages. [6]
The phage group started around 1940, after Delbrück and Luria had met at a physics conference. Delbrück and Salvador Luria began a series of collaborative experiments on the patterns of infection for different strains of bacteria and bacteriophage. They soon established the "mutual exclusion principle" that an individual bacterium can only be ...
A number of “vampire viruses” have been discovered in soil samples in Maryland and ... These particular viruses are caused when a bacteriophage latches onto a soil-based virus’s neck and ...
Phage therapy has many potential applications in human medicine as well as dentistry, veterinary science, and agriculture. [20] If the target host of a phage therapy treatment is not an animal, the term " biocontrol " (as in phage-mediated biocontrol of bacteria) is usually employed, rather than "phage therapy".