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Canine cognitive dysfunction (CCD) is a disease prevalent in dogs that exhibit symptoms of dementia or Alzheimer's disease shown in humans. [1] CCD creates pathological changes in the brain that slow the mental functioning of dogs resulting in loss of memory, motor function, and learned behaviors from training early in life.
Posterior cortical atrophy (PCA), also called Benson's syndrome, is a rare form of dementia which is considered a visual variant or an atypical variant of Alzheimer's disease (AD). [ 1 ] [ 2 ] [ 3 ] The disease causes atrophy of the posterior part of the cerebral cortex , resulting in the progressive disruption of complex visual processing . [ 4 ]
Like CJD, it can be mistaken for Alzheimer's dementia. Diagnosis is difficult, as pathognomonic signs on MRI such as cortical ribboning or hockey stick sign, periodic sharp wave complexes on EEG, and tests for 14-3-3 protein and tau protein are usually not helpful, and no mutations have been observed in the coding region of the PrP gene, unlike ...
Diagnosis. One example [9] of a combination of biomarkers that can accurately diagnose AD is: Changes in brain atrophy patterns over time (measured by MRI) Levels of β-amyloid and tau (measured in CSF) A second approach to diagnosis is to extract the most pertinent information from MRI scans alone. [9]
MRI image shows spinal bleeding (myelomalacia). Myelomalacia is a pathological term referring to the softening of the spinal cord. [ 1 ] Possible causes of myelomalacia include cervical myelopathy , hemorrhagic infarction , or acute injury, such as that caused by intervertebral disc extrusion.
Similar to the NINCDS-ADRDA Alzheimer's Criteria are the DSM-IV-TR criteria published by the American Psychiatric Association. [3] At the same time the advances in functional neuroimaging techniques such as PET or SPECT that have already proven their utility to differentiate Alzheimer's disease from other possible causes, [4] have led to proposals of revision of the NINCDS-ADRDA criteria that ...
Imagine: You and your sister are 66-year-old twins on Medicare who share the same family history of Alzheimer’s disease, making an early diagnosis critical for long-term planning and preventive ...
ARIA-E refers to cerebral edema, involving the breakdown of the tight endothelial junctions of the blood-brain barrier and subsequent accumulation of fluid. [3] In a double-blind trial of the humanised monoclonal antibody solanezumab (n = 2042), sixteen patients (11 taking the drug, 5 taking a placebo), or 0.78% developed ARIA-E.