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An illustrative diagram explaining drug resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. [1] The term is used in the context of resistance that pathogens or cancers have "acquired", that is, resistance has evolved.
drug sensitization or reverse tolerance – the escalating effect of a drug resulting from repeated administration at a given dose; drug withdrawal – symptoms that occur upon cessation of repeated drug use; physical dependence – dependence that involves persistent physical–somatic withdrawal symptoms (e.g., fatigue and delirium tremens)
In some cases, cancers can evolve resistance to multiple drugs, called multiple drug resistance. There are two general causes of antineoplastic therapy failure: Inherent genetic characteristics, giving cancer cells their resistance and acquired resistance after drug exposure, which is rooted in the concept of cancer cell heterogeneity. [1]
"With diet, you significantly want to increase your protein intake, and [with] exercise, changing those regimens to more of resistance training and weightlifting." Women turn to weight loss drugs ...
At one Narcotics Anonymous meeting, Patrick ran into two young women he knew from rehab. Those women could be bad news, he confessed to his mother one afternoon in their kitchen. Let’s get out the NA schedule and find a different meeting, Anne offered. Patrick told her he’d already found a later one to attend. He had it covered.
The number of pregnant women and new mothers dying from drug overdoses grew dramatically as the pandemic took hold, reaching a record high in 2020, a new study
The case of mother's milk is of special importance. The liver and kidneys of newly born infants are relatively undeveloped and they are highly sensitive to a drug's toxic effects. For this reason it is important to know if a drug is likely to be eliminated from a woman's body if she is breast feeding in order to avoid this situation.
This resistance occurs due to the development of escape pathways which provide new ways for cancer cells to survive in the presence of endocrine therapy. [18] If a patient with ER+ breast cancer develops endocrine resistance, the endocrine therapy used to treat the cancer will no longer be effective.