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[1] [2] EE is an estrogen, while norethisterone acetate (NETA) is a progestin. [1] It is taken by mouth . [ 1 ] Some preparations of EE/NETA used in birth control additionally contain an iron supplement in the form of ferrous fumarate .
Norethisterone and ethinylestradiol levels over 24 hours after a single oral dose of 10 mg NETA in postmenopausal women. [25] NETA metabolizes into ethinylestradiol at a rate of 0.20 to 0.33% across a dose range of 10 to 40 mg. [26] [27] Peak levels of ethinylestradiol with a 10, 20, or 40 mg dose of NETA were 58, 178, and 231 pg/mL, respectively.
1000 μg norethisterone acetate (UK: Loestrin 20, Galen; US: Loestrin 1/20, Duramed; Microgestin 1/20, Watson Pharmaceuticals; Junel 1/20, Barr) 1000 μg norethisterone acetate: 24 days + 4 days ferrous fumarate only (US: Loestrin 24 Fe, Warner Chilcott) 90 μg levonorgestrel: continuous: 365 days/year, no placebo (US: Amethyst, Watson)
Norethisterone is a substrate for and is known to be an inhibitor of 5α-reductase, with 4.4% and 20.1% inhibition at 0.1 and 1 μM, respectively. [11] However, therapeutic concentrations of norethisterone are in the low nanomolar range, so this action may not be clinically relevant at typical dosages.
Formulations and brand names of norethisterone and esters ; Composition Dose Brand names Use NET only: Low (e.g., 0.35 mg) Multiple [a]: Progestogen-only oral contraceptive: NET or NETA only
November 25, 2024 at 10:12 AM Testosterone Is a Female Hormone, Too Nastasic/Getty Images "Hearst Magazines and Yahoo may earn commission or revenue on some items through these links."
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