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In genetics, the coefficient of coincidence (c.o.c.) is a measure of interference in the formation of chromosomal crossovers during meiosis. It is generally the case that, if there is a crossover at one spot on a chromosome, this decreases the likelihood of a crossover in a nearby spot. [1] This is called interference.
The Kosambi mapping function was introduced to account for the impact played by crossover interference on recombination frequency. It introduces a parameter C, representing the coefficient of coincidence, and sets it equal to 2r. For loci which are strongly linked, interference is strong; otherwise, interference decreases towards zero. [5]
Crossover interference is the term used to refer to the non-random placement of crossovers with respect to each other during meiosis.The term is attributed to Hermann Joseph Muller, who observed that one crossover "interferes with the coincident occurrence of another crossing over in the same pair of chromosomes, and I have accordingly termed this phenomenon ‘interference’."
Journal of Bioinformatics and Computational Biology; Journal of Biomedical Informatics; Journal of Computational Biology; Journal of Mathematical Biology; Journal of Theoretical Biology; PLOS Computational Biology; Source Code for Biology and Medicine; Statistical Applications in Genetics and Molecular Biology; Statistics in Biosciences
The Annals of Human Genetics is a bimonthly peer-reviewed scientific journal covering human genetics. It was established in 1925 by Karl Pearson as the Annals of Eugenics , with as subtitle, Darwin's epigram "I have no Faith in anything short of actual measurement and the rule of three ". [ 1 ]
The trends in topics that have been published in the journal reflect the history of the discipline of genetics. [1] Early issues included many papers on eugenics, particularly under the editorial leadership of the journal's first two editors-in-chief, Paul Popenoe and R. C. Cook. Emphasis on eugenics in the journal declined throughout the 1940s and 1950s as support for the topic waned in the ...
Vertebrate genes and proteins have names (typically strings of words) and symbols, which are short identifiers (typically 3 to 8 characters). For example, the gene cytotoxic T-lymphocyte-associated protein 4 has the HGNC symbol CTLA4. These symbols are usually, but not always, coined by contraction or acronymic abbreviation of
It was established in 1967 and covers all topics related to the genetics of viruses, bacteria, fungi, plants, and animals, including humans. The current editor is Tatjana Piotrowski. [2] As of 2024, Journal Citation Reports gives the journal a 2023 impact factor of 8.7, ranking it eleventh out of 191 journals in the category "Genetics ...