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Dorzolamide, sold under the brand name Trusopt among others, is a medication used to treat high pressure inside the eye, including in cases of glaucoma. [3] It is used as an eye drop. [3] Effects begin within three hours and last for at least eight hours. [3] It is also available as the combination dorzolamide/timolol. [3] [4]
Visine (/ ˌ v aɪ ˈ z iː n /), also known as Vispring, is a brand of eye drops produced by Kenvue. [1] Visine was first introduced in 1958 and was acquired by Pfizer in 1999. [2] [3] In 2006, Johnson & Johnson acquired Visine, along with Pfizer's entire consumer healthcare portfolio. [4]
In one study, 10 people were given two drops of 0.5 mg/mL of tetryzoline eye drops (0.025–0.05 mg) at 0 hrs, 4 hrs, 8 hrs, and 12 hrs. Within a 24-hour time window, since the last dose of tetryzoline, the blood serum concentration of tetryzoline in the test subjects was 0.068-0.380 ng/mL and the urine concentration was 13–210 ng/mL. Both ...
An outer layer of the eye, called the corneal dome, does not have blood vessels that are usually critical in the immune system process because the eye “has to maintain a crystal clarity ...
The FDA recently cautioned against using dozens of kinds of eyedrops — its third warning this year — leading to some wondering whether any drops are safe to use. Eye doctors weigh in.
Serious side effects may include allergic reactions and heart failure. [3] Use is not recommended in those with asthma, a sulfonamide allergy, or a slow heart rate. [3] [7] Dorzolamide is a carbonic anhydrase inhibitor and timolol is a beta blocker. [3] Both work by decreasing the amount of aqueous humor made by the eye. [3]
The CDC warned that EzriCare Artificial Tears eyedrops may be linked to a drug-resistant bacterial infection that has caused permanent vision loss and one death.
The most important factor that must be taken into account when designing any type of drug delivery device, and specifically ocular devices, is the release rate of a drug. As discussed previously, the deliver rate and kinetics associated with drugs to the eye can reach levels that are toxic to the eye or could even cause undesirable side effects.