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HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. But contrary to other members of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer. [8]
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. [6]
The timeline of discovery of Solar System planets and their natural satellites charts the progress of the discovery of new bodies over history. Each object is listed in chronological order of its discovery (multiple dates occur when the moments of imaging, observation, and publication differ), identified through its various designations (including temporary and permanent schemes), and the ...
Download as PDF; Printable version; In other projects ... This list of exoplanets discovered in 2024 is a list of confirmed exoplanets that ... 455.0 +1.8 −1.7: 0. ...
July 23 – Comet Hale–Bopp is discovered by Alan Hale and Thomas Bopp independently. October 6 – 51 Pegasi b: Didier Queloz and Michel Mayor of the University of Geneva at the Observatoire de Haute-Provence announce the first definitive detection of an extrasolar planet orbiting an ordinary main sequence star [1] and the first "hot Jupiter".
The theory was initially proposed by Fred Hoyle in 1946, [1] who later refined it in 1954. [2] Further advances were made, especially to nucleosynthesis by neutron capture of the elements heavier than iron , by Margaret and Geoffrey Burbidge , William Alfred Fowler and Fred Hoyle in their famous 1957 B 2 FH paper , [ 3 ] which became one of the ...
Launch of Mariner 1 in 1962. The Mariner program was conducted by the American space agency NASA to explore other planets.Between 1962 and late 1973, NASA's Jet Propulsion Laboratory (JPL) designed and built 10 robotic interplanetary probes named Mariner to explore the inner Solar System – visiting the planets Venus, Mars and Mercury for the first time, and returning to Venus and Mars for ...
For example, if a TNO is incorrectly assumed to have a mass of 3.59 × 10 20 kg based on a radius of 350 km with a density of 2 g/cm 3 but is later discovered to have a radius of only 175 km with a density of 0.5 g/cm 3, its true mass would be only 1.12 × 10 19 kg.