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Breast cancer metastatic mouse models are experimental approaches in which mice are genetically manipulated to develop a mammary tumor leading to distant focal lesions of mammary epithelium created by metastasis. Mammary cancers in mice can be caused by genetic mutations that have been identified in human cancer. This means models can be ...
The laboratory mouse has physiology and genetic characteristics very similar to humans providing powerful models for investigation of the genetic characteristics of disease. [ 2 ] The Mouse Models of Human Cancer database (MMHCdb) is a unique, comprehensive online knowledgebase of mouse models of human cancer hosted by The Jackson Laboratory ...
Patient derived xenografts (PDX) are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunodeficient or humanized mouse. [1] It is a form of xenotransplantation.
4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse BALB/c strain. [1] 4T1 cells are epithelial and are resistant to 6-thioguanine. [1] In preclinical research, 4T1 cells have been used to study breast cancer metastasis as they can metastasize to the lung, liver, lymph nodes, brain and bone.
Crossbreeding with a reporter mice or inducible mice will generate multiple transgenes in the mammary gland as the promoter is mammary specific. Cells from new transgenic mice mammary glands can be transplanted in the cleared mammary fat pad or in lateral tail vein (in immunodeficient recipient mice) recipient to see the metastasis at ectopic ...
The organ tropism of patient-derived CTC has been investigated in a mouse model. [88] CTCs isolated from breast cancer patients and expanded in vitro showed they could generate bone, lung, ovary and brain metastases in mice, partially reflecting the secondary lesions as found in the corresponding patients. Remarkably, one CTC line—isolated ...
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Common sites of metastasis for breast cancer. Metastatic breast cancer, also referred to as metastases, advanced breast cancer, secondary tumors, secondaries or stage IV breast cancer, is a stage of breast cancer where the breast cancer cells have spread to distant sites beyond the axillary lymph nodes. There is no cure for metastatic breast ...