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Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom). A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, [1] providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensation in the entire body and causes ...
This is a list of local anesthetic agents. Not all of these drugs are still used in clinical practice and in research. ... Amide benzocaine: Anbesol, Orajel Ester ...
Articaine is a dental amide-type local anesthetic. It is the most widely used local anesthetic in a number of European countries [2] and is available in many countries. It is the only local anaesthetic to contain a thiophene ring, meaning it can be described as 'thiophenic'; this conveys lipid solubility. [3]
Etidocaine, marketed under the trade name Duranest, is an amide-type local anesthetic given by injection during surgical procedures and labor and delivery.Etidocaine has a long duration of activity, and the main disadvantage of using during dentistry is increased bleeding during surgery.
Lidocaine, the first amino amide–type local anesthetic (previous were amino esters), was first synthesized under the name 'xylocaine' by Swedish chemist Nils Löfgren in 1943. [60] [61] [62] His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself. [60] It was first marketed in 1949.
Leaves of the coca plant (Erythroxylum novogranatense var. Novogranatense), from which cocaine, a naturally occurring local anesthetic, is derived [1] [2]. An anesthetic (American English) or anaesthetic (British English; see spelling differences) is a drug used to induce anesthesia — in other words, to result in a temporary loss of sensation or awareness.
Like other local anesthetics belonging in the amide group trimecaine decreases the cell membrane permeability, causes depolarization and shortens the action potential. [3] Anesthetic effect starts within 15 minutes and remains 60–90 minutes. Its biological half-life is ca. 90 minutes. 10% of trimecaine is excreted unchanged (90% as its ...
Prilocaine (/ ˈ p r aɪ l ə ˌ k eɪ n / [1]) is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Löfgren.In its injectable form (trade name Citanest), it is often used in dentistry.