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Dexmethylphenidate has a 4–6 hour duration of effect. A long-acting formulation, Focalin XR, which spans 12 hours is also available and has been shown to be as effective as DL (dextro-, levo-)-TMP (threo-methylphenidate) XR (extended release) (Concerta, Ritalin LA), with flexible dosing and good tolerability.
Molindone [extended-release] (AFX-2201, EN-1733A, molindone XR, SPN-810, SPN-810M, Zalvari) – antipsychotic / dopamine D 2 receptor antagonist and serotonin receptor modulator (e.g., serotonin 5-HT 2B and 5-HT 2A receptor antagonist) — specifically under development for impulsive aggression in ADHD [6] [7] [8]
These new systems include pellets of medication coated with various time-release substances to permit medications to dissolve hourly across an 8–12 hour period (Metadate CD, Adderall XR, Focalin XR) and an osmotic pump that extrudes a liquid methylphenidate sludge across an 8–12 hour period after ingestion (Concerta). [citation needed]
Amid ongoing ADHD drug shortages, Adderall supplies have improved, ... Vyvanse, even with generic versions recently approved, is still hard to come by, she said; so is Ritalin and Focalin.
The list is ordered alphabetically according to the condition or conditions, then by the generic name of each medication. The list is not exhaustive and not all drugs are used regularly in all countries. Some medications treat multiple conditions and appear multiple times.
The stolen controlled substances included Dextroamphetamine-Amphetamine ER, Vyvanse, Methylphenidate, Adderall XR and Focalin XR, according to court records. These drugs are often used to treat ADHD.
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The variant with optimized efficacy is not the usually attested generic or common pharmaceutical brands (e.g. Ritalin, Daytrana etc.) but the (R,R)-dextro-(+)-threo-anti (sold as Focalin), which has a binding profile on par with or better than that of cocaine.