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Organophosphate poisoning is poisoning due to organophosphates (OPs). [4] ... Animals exposed in utero to chlorpyrifos exhibited decreased balance, poorer cliff ...
Organophosphate insecticides are acetylcholinesterase inhibitors, which disrupt the transmission of nerve signals in exposed organisms, with fatal results. The risk of human death through organophosphate poisoning [33] was obvious from the start and led to efforts to lower toxicity against mammals while not reducing efficacy against insects ...
Chlorpyrifos (CPS), also known as chlorpyrifos ethyl, is an organophosphate pesticide that has been used on crops, and animals in buildings, and in other settings, to kill several pests, including insects and worms. It acts on the nervous systems of insects by inhibiting the acetylcholinesterase enzyme.
Organophosphate poisoning is not common in the developed world. Most cases of terbufos poisoning occur in the developing world, where protection against pesticides is scarce, but compounds such as terbufos are widespread, uncontrolled by a government and readily available for farmers.
Organophosphate insecticides and chemical warfare nerve agents (such as sarin, tabun, soman, and VX) have the same mechanism of action. Organophosphates have a cumulative toxic effect to wildlife, so multiple exposures to the chemicals amplifies the toxicity. [19] In the US, organophosphate use declined with the rise of substitutes. [20]
Paraoxon is one of the most potent acetylcholinesterase-inhibiting insecticides available, around 70% as potent as the nerve agent sarin, and so is now rarely used as an insecticide due to the risk of poisoning to humans and other animals. Paraoxon has been used by scientists to study acute and chronic effects of organophosphate intoxication.
After arriving back home, the couple sought medical attention and were diagnosed with "likely organophosphate poisoning." Organophosphates are a type of human-made chemicals that are widely used ...
Possible effects on animals are endocrine disruption, reproductive and immune dysfunction and cancer. [22] A remarkable phenomenon that has been demonstrated in numerous animal studies is that repeated exposure to organophosphates causes the mammals to be less susceptible to the toxic effects of the AChE inhibitors, even though cholinesterase ...