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This has been used in the GEMCOVAC-19 vaccine with the saRNA being adsorbed on the surface of the LION nano-lipid emulsion and has received emergency licensure in India. [11] A second saRNA for COVID-19, ARCT-154, was developed by Arcturus Therapeutics. A version manufactured by Meiji Seika Pharma was authorised in Japan in November 2023.
To identify an saRNA that can activate a gene of interest, several saRNAs need to be designed within a 1- to 2-kbp promoter region by following a set of rules [3] [4] and tested in cultured cells. In some reports, saRNAs are designed in such a way to target non-coding transcripts that overlap the promoter sequence of a protein coding gene.
The term "Sarna", derived from the Mundari language, means "sacred grove", referring to the sites where tribal religious practices take place, although the term for sacred grove varies among tribes; for instance, the Santals call it Jaher Era, Oraons call it Kurukh Kuti, Hos call it Desauli.
Gritstone bio started also started a phase 1 trial of an saRNA COVID-19 vaccine in 2021, used as a booster vaccine, with interim results published in 2023. [105] The vaccine is designed to target both the spike protein of the SARS‑CoV‑2 virus, and viral proteins that may be less prone to genetic variation, to provide greater protection ...
James Carville slammed what the longtime Democratic strategist called “NPR language” that he said members of his party use as he evaluated why Vice President Harris lost the November election.
Most of population is Sarna, which is a religion that is indigenous to Adivasis in the Chota Nagpur Plateau. Sarna perform religious rituals under the shade of a sacred grove. They worship the sun as Biri and the moon as Chando, and call the earth Dharti Aayo (Earth as mother). Chando Biri are the words which are used in Sarna pujas.
Sarna Burhi is described as being a goddess associated with spirits, rain, and plants. In the culture of the Munda and Kurukh peoples (both of which constitute part of the Adivasi peoples), [1] [2] Sarna Burhi is depicted as the guardian of Sarna, sacred groves of trees that serve as refuges for spirits displaced by human activity. [3]
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