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Mechanism of self-amplifying mRNA (saRNA) used for antigen production. The ORF encoding the antigen can also be substituted with a protein for use in protein replacement therapy. This sequence encodes the protein of interest, used as an antigen in the case of vaccines or for protein replacement therapies. The gene of interest replaces the viral ...
To identify an saRNA that can activate a gene of interest, several saRNAs need to be designed within a 1- to 2-kbp promoter region by following a set of rules [3] [4] and tested in cultured cells. In some reports, saRNAs are designed in such a way to target non-coding transcripts that overlap the promoter sequence of a protein coding gene.
Gritstone bio started also started a phase 1 trial of an saRNA COVID-19 vaccine in 2021, used as a booster vaccine, with interim results published in 2023. [105] The vaccine is designed to target both the spike protein of the SARS‑CoV‑2 virus, and viral proteins that may be less prone to genetic variation, to provide greater protection ...
Sarnaism is a religious faith of the Indian subcontinent, predominantly followed by indigenous communities of Chota Nagpur Plateau region across states like Jharkhand, Odisha, West Bengal, Bihar, and Chhattisgarh.
Nahum Sarna was born in London in 1923 to Jacob J. Sarna and Milly (Horonzick) Sarna, [1] and received his M.A. from the University of London in 1946, and a degree from Jews College in 1947. He married Hebrew College librarian Helen Horowitz on March 23, 1947, and was a Lecturer at University College London from 1946 to 1949. [ 2 ]
Most of population is Sarna, which is a religion that is indigenous to Adivasis in the Chota Nagpur Plateau. Sarna perform religious rituals under the shade of a sacred grove. They worship the sun as Biri and the moon as Chando, and call the earth Dharti Aayo (Earth as mother). Chando Biri are the words which are used in Sarna pujas.
Former producer Sim Sarna used to participate in the second part of the show, which consisted of Sarna, Faris and the guest placing a phone call to a listener who has a relationship or personal dilemma and seeks "unqualified" advice. Since Sarna's leaving, the segment has been conducted primarily by Anna and guests. [1]
Sarna Burhi is described as being a goddess associated with spirits, rain, and plants. In the culture of the Munda and Kurukh peoples (both of which constitute part of the Adivasi peoples), [1] [2] Sarna Burhi is depicted as the guardian of Sarna, sacred groves of trees that serve as refuges for spirits displaced by human activity. [3]