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CA-125 was initially detected using the murine monoclonal antibody designated OC125. Robert Bast , Robert Knapp and their research team first isolated this monoclonal antibody in 1981. [ 28 ] The protein was named "cancer antigen 125" because OC125 was the 125th antibody produced against the ovarian cancer cell line that was being studied.
125 I is a gamma emitter with a long half-life of 59.4 days (the longest of all radioiodines used in medicine). Iodine-123 is preferred for imaging, so I-125 is used diagnostically only when the test requires a longer period to prepare the radiopharmaceutical and trace it, such as a fibrinogen scan to diagnose clotting.
A fibrinogen uptake test is a test that was formerly used to detect deep vein thrombosis. Radioactive labeled fibrinogen is given which is incorporated in the thrombus. The thrombus can then be detected by scintigraphy. [1] [2] Iodine 125-labeled fibrinogen scanning is a very sensitive method for detecting subclinical leg vein thrombi.
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As with any test that screens for disease, the risks of full-body CT scans need to be weighed against the benefit of identifying a treatable disease at an early stage. [6] An alternative to a full-body CT scan may be Magnetic resonance imaging (MRI) scans. MRI scans are generally more expensive than CT but do not expose the patient to ionizing ...
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The Agatston score, named after its developer Arthur Agatston, is a measure of calcium on a coronary CT calcium scan. [7] The original work, published in 1990, [8] was based on electron beam computed tomography (also known as ultrafast CT or EBCT). The score is calculated using a weighted value assigned to the highest density of calcification ...
Iodine-123 (123 I) is a radioactive isotope of iodine used in nuclear medicine imaging, including single-photon emission computed tomography (SPECT) or SPECT/CT exams. The isotope's half-life is 13.2232 hours; [1] the decay by electron capture to tellurium-123 emits gamma radiation with a predominant energy of 159 keV (this is the gamma primarily used for imaging).