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Mechanism of self-amplifying mRNA (saRNA) used for antigen production. The ORF encoding the antigen can also be substituted with a protein for use in protein replacement therapy. This sequence encodes the protein of interest, used as an antigen in the case of vaccines or for protein replacement therapies. The gene of interest replaces the viral ...
Therapeutic use of saRNAs have been suggested. They have been tested in animal models to treat bladder tumors, [8] liver carcinogenesis, [9] [10] pancreatic cancer, [11] and erectile dysfunction. [12] In 2016, a phase I clinical trial involving advanced liver cancer patients [13] was launched for the saRNA drug MTL-CEBPA. It aimed to complete ...
A baked potato is sometimes called a jacket potato in the United Kingdom. The baked potato has been popular in the UK for many years. In the mid-19th century, jacket potatoes were sold on the streets by hawkers during the autumn and winter months. In London, it was estimated that some 10 tons of baked potatoes were sold each day by this method ...
Aluminum foil can stop baked potatoes from getting crisp on the outside. Hrecheniuk Oleksii/Shutterstock For the perfect baked potato with a fluffy interior and crispy skin, avoid using aluminum foil.
Place on a baking sheet or on a heatproof rack inserted inside a baking sheet. Bake potatoes until easily pierced with a fork and an instant-read thermometer inserted into the center registers 200 ...
Baked and Loaded Potatoes. Perhaps the simplest of all to prepare, the humble baked potato can be a side or main dish. Prick a few holes in a potato and place in a 350-degree oven until tender ...
In addition to the cases where the tubers are cooked and served with their skins, for example new potatoes, one can also make appetizers in the form of potato peel chips, or fritters, by dipping peels taken from boiled potatoes in a fritter batter. Baked potatoes cut in half and scooped out with a spoon can be used to make nests, which can be ...
Prick potatoes with a fork before baking to shorten the baking time and to keep them from bursting. Place the potatoes on an unlined baking sheet and bake at 400 F for about one hour, or until tender.