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  2. Immunoglobulin E - Wikipedia

    en.wikipedia.org/wiki/Immunoglobulin_E

    Specific IgE testing is the proven test for allergy detection; evidence does not show that indiscriminate IgE testing or testing for immunoglobulin G (IgG) can support allergy diagnosis. [ 34 ] Drugs targeting the IgE pathway

  3. Type I hypersensitivity - Wikipedia

    en.wikipedia.org/wiki/Type_I_hypersensitivity

    In type I hypersensitivity, B cells are stimulated (by CD4 + T h 2 cells) to produce IgE antibodies specific to an antigen. The difference between a normal infectious immune response and a type 1 hypersensitivity response is that in type 1 hypersensitivity, the antibody is IgE instead of IgA, IgG, or IgM.

  4. Hyperimmunoglobulin E syndrome - Wikipedia

    en.wikipedia.org/wiki/Hyperimmunoglobulin_E_syndrome

    Most patients with hyper IgE syndrome are treated with long-term antibiotic therapy to prevent staphylococcal infections. Good skin care is also important in patients with hyper IgE syndrome. High-dose intravenous gamma-globulin has also been suggested for the treatment of severe eczema in patients with HIES and atopic dermatitis. [21]

  5. FCER1 - Wikipedia

    en.wikipedia.org/wiki/FCER1

    The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in allergy disorders and parasite immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE. [1]

  6. Type 2 inflammation - Wikipedia

    en.wikipedia.org/wiki/Type_2_inflammation

    IL-4 further drives CD4+ T cell differentiation towards the T h 2 subtype and induces isotype switching to IgE in B cells. IL-4 and IL-13 stimulate trafficking of eosinophils to the site of inflammation, while IL-5 promotes both eosinophil trafficking and production.

  7. Interleukin 13 - Wikipedia

    en.wikipedia.org/wiki/Interleukin_13

    Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation. [7] It is a mediator of allergic inflammation and different diseases including asthma , [ 7 ] and atopic dermatitis .

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  9. Interleukin 4 - Wikipedia

    en.wikipedia.org/wiki/Interleukin_4

    It is a key regulator in humoral and adaptive immunity. IL-4 induces B cell class switching to IgE, and up-regulates MHC class II production. IL-4 decreases the production of T h 1 cells, macrophages, IFNγ, and dendritic cells IL-12. Overproduction of IL-4 is associated with allergies. [5]