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The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
Growth and development of new neuron; The neurogenesis hypothesis of depression posits that: [3] Stressful experiences have a negative effect on the process of neurogenesis in the subgranular zone of the dentate gyrus. Alternations in the rate of neurogenesis play a fundamental role in the pathology and treatment of major depression.
One reason depression is thought to be a pathology is that it causes so much psychic pain and distress. However, physical pain is also very distressful, yet it has an evolved function: to inform the organism that it is being damaged, to motivate it to withdraw from the source of damage, and to learn to avoid such damage-causing circumstances in the future.
The new definitions of depression were widely accepted, albeit with some conflicting findings and views, and the nomenclature continues in DSM-IV-TR, published in 2000. [ 39 ] There has been some criticism of the expansion of coverage of the diagnosis, related to the development and promotion of antidepressants and the biological model since ...
A new analysis from the University of Castilla–La Mancha in Spain, which interpreted data from more than 96,000 adults, found that those who took more steps during their day also had fewer ...
Depression (kinesiology), an anatomical term of motion, refers to downward movement, the opposite of elevation; Depression (physiology), a reduction in a biological variable or the function of an organ; Central nervous system depression, physiological depression of the central nervous system that can result in loss of consciousness
Findings from a study in 2006 of a community sample of youth supported the tripartite in youth and further supported that anxiety and depression do represent unique syndromes in youth based on differences found in positive affect. [22] Many studies looked at samples of youth but studies were also done with older adult samples.
Findings have been mixed, but some studies suggest that cognitive deficit is more related to neglect than other forms of adversity. [85] [86] Poor parenting is a risk factor for depression and anxiety. Separation, grief in families, and other forms childhood trauma are risk factors for schizophrenia. [87]