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The synapse is the primary unit of information transfer in the nervous system, and correct synaptic contact creation during development is essential for normal brain function. In addition, several mutations have been connected to neurodevelopmental disorders, and that compromised function at different synapse locations is a hallmark of ...
Whether a synapse is excitatory or inhibitory depends on what type(s) of ion channel conduct the postsynaptic current(s), which in turn is a function of the type of receptors and neurotransmitter employed at the synapse.
In immunology, an immunological synapse (or immune synapse) is the interface between an antigen-presenting cell or target cell and a lymphocyte such as a T cell, B cell, or natural killer cell. The interface was originally named after the neuronal synapse , with which it shares the main structural pattern. [ 1 ]
Synaptogenesis is the formation of synapses between neurons in the nervous system.Although it occurs throughout a healthy person's lifespan, an explosion of synapse formation occurs during early brain development, known as exuberant synaptogenesis. [1]
Animation showing the function of a chemical synapse. There are two different kinds of synapses present within the human brain: chemical and electrical. Chemical synapses are by far the most prevalent and are the main player involved in excitatory synapses.
A diagram of the proteins found in the active zone. The active zone is present in all chemical synapses examined so far and is present in all animal species. The active zones examined so far have at least two features in common, they all have protein dense material that project from the membrane and tethers synaptic vesicles close to the membrane and they have long filamentous projections ...
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These vesicles are large, consistent with the findings regarding quantal size in other adult synapses. Dense-core vesicles, usually containing neuropeptides, are also present, but further research is needed to determine their content and function. [15] To maintain the structure of the synapse, as with other synapses, there are many microtubules ...