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In an update published in 2011 ("Hallmarks of cancer: the next generation"), Weinberg and Hanahan proposed two new hallmarks: (1) abnormal metabolic pathways and (2) evasion of the immune system, and two enabling characteristics: (1) genome instability, and (2) inflammation. [2]
With Robert Weinberg, he wrote a seminal paper The Hallmarks of Cancer, published in January 2000, and which in March 2011 is the most cited article from the peer reviewed journal Cell. [5] In 2011, they published an updated review article entitled "Hallmarks of cancer: the next generation". [6]
He and Douglas Hanahan wrote the seminal paper "The Hallmarks of Cancer", published in January 2000, [9] that gave the six requirements for one renegade cell to cause a deadly cancer: [8] In 2011, they published an updated review article entitled "Hallmarks of cancer: the next generation".
“Inflammation is, in fact, one of the ‘hallmarks’ of cancer.” Inflammation, at its core, is a good thing. It’s part of the body’s immune response, and the reason we don’t die every ...
The Hallmarks of Cancer, published in 2000, and Hallmarks of Cancer: The Next Generation, published in 2011, by Douglas Hanahan and Robert Weinberg. Together, these articles have been cited in over 30,000 published papers.
In their landmark paper, The Hallmarks of Cancer, [3] Hanahan and Weinberg suggest that cancer can be described by a small number of underlying principles, despite the complexities of the disease. The authors describe how tumor progression proceeds via a process analogous to Darwinian evolution, where each genetic change confers a growth ...
Proliferation, as one of the hallmarks and most fundamental biological processes in tumors, [1] is associated with tumor progression, response to therapy, and cancer patient survival. [2] Consequently, the evaluation of a tumor proliferative index (or growth fraction) has clinical significance in characterizing many solid tumors and hematologic ...
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