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In 1986, it was presumed that permanent brain damage may result from chronic use of benzodiazepines similar to alcohol-related brain damage. [ 70 ] In 1987, 17 inpatient people who used high doses of benzodiazepines non-medically have anecdotally shown enlarged cerebrospinal fluid spaces with associated cerebral atrophy .
Alprazolam, sold under the brand name Xanax among others, is a fast-acting, potent tranquilizer of moderate duration within the triazolobenzodiazepine group of chemicals called benzodiazepines. [15] Alprazolam is most commonly prescribed in the management of anxiety disorders , especially panic disorder and generalized anxiety disorder (GAD). [ 9 ]
Abrupt withdrawal can be dangerous and lead to excitotoxicity, causing damage and even death to nerve cells as a result of excessive levels of the excitatory neurotransmitter glutamate. Increased glutamatergic activity is thought to be part of a compensatory mechanism to chronic GABAergic inhibition from benzodiazepines.
Leukopenia and liver-damage of the cholestatic type with or without jaundice (icterus) have additionally been seen; the original manufacturer Roche recommends regular laboratory examinations to be performed routinely. Ambulatory patients should be warned that bromazepam may impair the ability to drive vehicles and to operate machinery.
Data from the Drug Induced Liver Injury Network show that rates of liver injury from botanical products jumped from seven percent in 2004-2005 to 20 percent in 2013-2014.
Fatty liver disease happens when fat builds up in your liver. This can cause damage, inflammation, and other complications. There are two main types of fatty liver disease:
Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
An onslaught of common childhood viruses may have been behind the mysterious outbreak of cases of severe liver damage in children that began popping up in late 2021, ... which can cause mononucleosis.