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The CTCAE system is a product of the US National Cancer Institute (NCI). The first Iteration was prior to 1998. In 1999, the FDA released version 2.0. CTCAE version 4.0 in 2009 with an update to y version 4.03 in 2010. [2] The current version 5.0 was released on November 27, 2017.
The geologic time scale is a way of representing deep time based on events that have occurred throughout Earth's history, a time span of about 4.54 ± 0.05 Ga (4.54 billion years). [3]