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Signs of hyperestrogenism may include heightened levels of one or more of the estrogen sex hormones (usually estradiol and/or estrone), lowered levels of follicle-stimulating hormone and/or luteinizing hormone (due to suppression of the hypothalamic–pituitary–gonadal axis by estrogen), and lowered levels of androgens such as testosterone (generally only relevant to males). [1]
Aromatase excess syndrome (AES or AEXS) is a rarely diagnosed genetic and endocrine syndrome which is characterized by an overexpression of aromatase, the enzyme responsible for the biosynthesis of the estrogen sex hormones from the androgens, in turn resulting in excessive levels of circulating estrogens and, accordingly, symptoms of hyperestrogenism.
Men and women exhibit different symptoms for hypergonadism. A few of the symptoms that men can experience are increased sex drive, early balding, excessive muscle mass, and acne. Women can have symptoms such as, increased growth of facial hair, deepened voice, coarse body hair, and an irregular menstrual cycle. [5]
ALS occurs more commonly in men than in women, and women get the disease later in life compared to men. [12] This suggested the possible protective role of estrogen in ALS. By conducting treatment of 17β-estradiol to ovariectomy treated mice, scientists found significantly delay of disease progression. [13]
Men with breast cancer have an absolute risk of presenting with a second cancer in their other breast of 1.75, i.e. they have a 75% increase of developing a contralateral breast cancer over their lifetimes compared to men who develop a breast cancer without having had a prior breast cancer. [5]
Too much estrogen in a male body is not a good thing; it can cause erectile dysfunction, or low libido." Elevated levels can also strain the heart and cause other muscle and ligament damage.
At just 19 years old, Eldiara Doucette — known on social media as "Bionic Barbie" — was diagnosed with synovial sarcoma, a rare form of soft tissue cancer that affects only 1,000 people per ...
For example, a 2022 review in Cancer Medicine suggests too much iron can increase the risk of lung and colorectal cancers, noting that excess iron may fuel tumor growth.