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List of side effects of estradiol which may occur as a result of its use or have been associated with estrogen and/or progestogen therapy includes: [1] [2]. Gynecological: changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia ...
Side effects of estradiol acetate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [7] [5] [6] Estradiol acetate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [8] [9] It is an estrogen ester and a prodrug of estradiol in the body.
This may look like lifestyle changes (think: diet and exercise), cognitive behavioral therapy (which Dr. Rosser says is still the gold standard for managing sleep issues), or hormone therapy.
Headache, breast pain or tenderness, nausea, vomiting, hair loss, vaginal discharge or irritation, and mood changes are some of the common side effects that may occur while using an estrogen patch. [10] More serious side effects may include fever, loss of appetite, joint pain, difficulty breathing or swallowing, and yellowing of the skin or eyes.
The timing of starting estrogen therapy could also be important. One study from 2016 showed that there was more cardiovascular benefit when HRT was started within 6 years of menopause than when it ...
Examples of such side effects include breast tenderness and enlargement, nausea, bloating, edema, headache, and melasma. [15] [62] High-dose estrogen therapy with estradiol valerate injections may also cause an increased risk of thromboembolism, changes in blood lipid profile, increased insulin resistance, and increased levels of prolactin. [62]
Research is still ongoing regarding the effects of GLP-1s on bone density, which is a common concern for women during menopause. ( Up to 20 percent of bone loss can occur during this time.)
As unopposed estrogen therapy (using estrogen alone without progesterone) increases the risk of endometrial hyperplasia and endometrial cancer in women with intact uteruses, estradiol is usually combined with a progestogen like progesterone or medroxyprogesterone acetate to prevent the effects of estradiol on the endometrium.