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Half-life (symbol t ½) is the time required for a quantity (of substance) to reduce to half of its initial value.The term is commonly used in nuclear physics to describe how quickly unstable atoms undergo radioactive decay or how long stable atoms survive.
An effective half-life of the drug will involve a decay constant that represents the sum of the biological and physical decay constants, as in the formula: = + With the decay constant it is possible to calculate the effective half-life using the formula:
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
The half-life of this isotope is 6.480 days, [2] which corresponds to a total decay constant of 0.1070 d −1. Then the partial decay constants, as computed from the branching fractions, are 0.1050 d −1 for ε/β + decays, and 2.14×10 −4 d −1 for β − decays. Their respective partial half-lives are 6.603 d and 347 d.
The absorption rate constant K a is a value used in pharmacokinetics to describe the rate at which a drug enters into the system. It is expressed in units of time −1. [1] The K a is related to the absorption half-life (t 1/2a) per the following equation: K a = ln(2) / t 1/2a.
Specific activity (symbol a) is the activity per unit mass of a radionuclide and is a physical property of that radionuclide. [1] [2] It is usually given in units of becquerel per kilogram (Bq/kg), but another commonly used unit of specific activity is the curie per gram (Ci/g).
But is also equivalent to divided by elimination rate half-life /, = /. Thus, = /. This means, for example, that an increase in total clearance results in a decrease in elimination rate half-life, provided distribution volume is constant.
Carbon (6 C) has 14 known isotopes, from 8 C to 20 C as well as 22 C, of which 12 C and 13 C are stable.The longest-lived radioisotope is 14 C, with a half-life of 5.70(3) × 10 3 years. . This is also the only carbon radioisotope found in nature, as trace quantities are formed cosmogenically by the reactio