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Transcription factor AP-2 gamma also known as AP2-gamma is a protein that in humans is encoded by the TFAP2C gene. [5] AP2-gamma is a member of the activating protein 2 family of transcription factors. Transcription factor AP-2 gamma is involved in early development, specifically morphogenesis - the formation of shape.
Bidirectional transcription at enhancer sites generates comparatively shorter (0.5-2kb) and non-polyadenylated eRNAs. Enhancers that generate polyA- eRNAs have a chromatin signature with a higher H3K4me1/me3 ratio than 1D-eRNAs. In general, enhancer transcription and production of bidirectional eRNAs demonstrate a strong correlation of enhancer ...
83383 Ensembl ENSG00000090447 ENSMUSG00000005718 UniProt Q01664 Q9JIZ5 RefSeq (mRNA) NM_003223 NM_031182 RefSeq (protein) NP_003214 NP_112459 Location (UCSC) Chr 16: 4.26 – 4.27 Mb Chr 16: 4.36 – 4.38 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by ...
In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins to increase the likelihood that transcription of a particular gene will occur. [1] [2] These proteins are usually referred to as transcription factors. Enhancers are cis-acting. They can be located up to 1 Mbp (1,000,000 bp) away from the gene ...
Transcription factors can be divided in two main categories: activators and repressors. While activators can interact directly or indirectly with the core machinery of transcription through enhancer binding, repressors predominantly recruit co-repressor complexes leading to transcriptional repression by chromatin condensation of enhancer regions.
As a result, the enhanceosome also recruits non histone architectural transcription factors, called high-mobility group (HMG) proteins, which are responsible for regulating chromatin structure. [3] These factors do not bind to the enhancer, but instead are used to restructure the DNA to ensure that the genes can be accessed by the transcription ...
AP-2 beta is a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development.
Activating Protein 2 (AP-2) is a family of closely related transcription factors [1] [2] which plays a critical role in regulating gene expression during early development. [ 3 ] References