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Vitamin D regulates proconvulsant and anticonvulsant factors. More specifically, Vitamin D is involved in the down regulation of cytokine IL-6, which is a proconvulsant. [7] Additionally, vitamin D is associated with the up regulation of neurotrophic factors: GDNF and TN3. These neurotrophic factors are anticonvulsant. In the absence or ...
Anticonvulsants suppress the excessive rapid firing of neurons during seizures. [6] Anticonvulsants also prevent the spread of the seizure within the brain. [7] Conventional antiepileptic drugs may block sodium channels or enhance γ-aminobutyric acid function. Several antiepileptic drugs have multiple or uncertain mechanisms of action. [8]
[citation needed] Bemegride and flumazenil are used to treat drug overdoses (of barbiturates and benzodiazepines respectively), but may cause convulsions if the dose is too high. [8] [9] Convulsants are also widely used in scientific research, for instance in the testing of new anticonvulsant drugs. Convulsions are induced in captive animals ...
Particular medications can result in MRONJ, a serious but uncommon side effect in certain individuals. Such medications are frequently used to treat diseases that cause bone resorption such as osteoporosis, or to treat cancer. The main groups of drugs involved are anti-resorptive drugs, and anti-angiogenic drugs.
The drug is occasionally used on an intermittent basis to prevent seizures in catamenial epilepsy. [10] The sulfur-containing antiseizure and antimigraine drug topiramate is a weak inhibitor of carbonic anhydrase, particularly subtypes II and IV. [11] Whether carbonic anhydrase inhibition contributes to its clinical activity is not known.
This kind of adverse drug reaction is caused by the accumulation of toxic metabolites; it is not the result of an IgE-mediated reaction. The risk of first-degree relatives developing the same hypersensitivity reaction is higher than in the general population. [1]
Steroid-induced osteoporosis is osteoporosis arising from the use of glucocorticoids (a class of steroid hormones) analogous to Cushing's syndrome but involving mainly the axial skeleton. The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake.
This is a list of drugs and substances that are known or suspected to cause Stevens–Johnson syndrome This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources .