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The mixture of cannabinoids produced by a plant is known as the plant's cannabinoid profile. Selective breeding has been used to control the genetics of plants and modify the cannabinoid profile. For example, strains that are used as fiber (commonly called hemp ) are bred such that they are low in psychoactive chemicals like THC.
Cannabinoids and their K i values [a] Name Class K i / nM at CB 1 K i / nM at CB 2 Selectivity Structure JWH-004: Naphthoylindole: 48 ± 13: 4 ± 1.5: CB 2 (12x) JWH ...
Alanine transaminase (ALT), also known as alanine aminotransferase (ALT or ALAT), formerly serum glutamate-pyruvate transaminase (GPT) or serum glutamic-pyruvic transaminase (SGPT), is a transaminase enzyme (EC 2.6.1.2) that was first characterized in the mid-1950s by Arthur Karmen and colleagues. [1]
WIN 55,212-2 is a potent cannabinoid receptor agonist [6] that has been found to be a potent analgesic [7] in a rat model of neuropathic pain. [8] It activates p42 and p44 MAP kinase via receptor-mediated signaling. [9] At 5 μM WIN 55,212-2 inhibits ATP production in sperm in a CB 1 receptor-dependent fashion. [10]
These unprecedented synthetic cannabinoids often feature alphanumeric code names intended to mimic the style of chemical nomenclature used by academic laboratories and pharmaceutical companies, and there is generally little, if any, information available regarding their pharmacology and toxicology at the time of first discovery.
Another name for JWH-018, it is a full agonist at both cannabinoid receptors with some selectivity for CB 2. AM-679: 13.5: 49.5: 6.04: An iodobenzoylindole which acts as a moderately potent agonist for both cannabinoid receptors. AM-694: 0.08: 1.44: CB 1 (18×) 5.54: An iodobenzoylindole which acts as a potent and selective agonist for the CB 1 ...
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Classical cannabinoids are analogs of THC that are based on a dibenzopyran ring. They were developed starting in the 1960s, following the isolation of THC, [50] and were originally the only cannabinoids synthesized. [84] Classical cannabinoids include nabilone and dronabinol, and one of the best known synthetic classical cannabinoids is HU-210 ...