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However, single nucleotide polymorphism (SNP) is one of many mechanisms that leads to increased risk for type 2 diabetes. To locate genes and loci that are responsible for the risk of type 2 diabetes, genome wide association studies (GWAS) was utilized to compare the genomes of diabetic patient group and the non-diabetic control group. [4]
Maturity-onset diabetes of the young (MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. [1] Along with neonatal diabetes , MODY is a form of the conditions known as monogenic diabetes.
22393 Ensembl ENSG00000109501 ENSMUSG00000039474 UniProt O76024 P56695 RefSeq (mRNA) NM_006005 NM_001145853 NM_011716 RefSeq (protein) NP_001139325 NP_005996 NP_035846 Location (UCSC) Chr 4: 6.27 – 6.3 Mb Chr 5: 37.12 – 37.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Wolframin is a protein that in humans is encoded by the WFS1 gene. Function This gene encodes a ...
6524 246787 Ensembl ENSG00000140675 ENSMUSG00000030781 UniProt P31639 Q923I7 RefSeq (mRNA) NM_003041 NM_133254 RefSeq (protein) NP_003032 NP_573517 Location (UCSC) Chr 16: 31.48 – 31.49 Mb Chr 7: 127.86 – 127.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The sodium/glucose cotransporter 2 (SGLT2) is a protein that in humans is encoded by the SLC5A2 (solute carrier family 5 ...
Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia. Glucokinase (GK) is a hexokinase isozyme , related homologously to at least three other hexokinases. [ 4 ] All of the hexokinases can mediate phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and ...
Type 2 diabetes makes up about 90% of cases of diabetes, with the other 10% due primarily to type 1 diabetes and gestational diabetes. [1] In type 1 diabetes, there is a lower total level of insulin to control blood glucose, due to an autoimmune -induced loss of insulin-producing beta cells in the pancreas .
Prentice et al. [17] predicted that the emerging molecular genetics field would ultimately provide a way to test between the adaptive 'thrifty gene' idea and the non-adaptive 'drifty gene' idea because it would be possible to find signatures of positive selection in the human genome, at genes that are linked to both obesity and type 2 diabetes ...
IDDM11 (insulin-dependent diabetes mellitus 11) is one of the susceptibility genes for IDDM which locates on chromosome 14q24.3-q31. [ 2 ] [ 6 ] This loci is identified by linkage to D14S67 marker via a sibling-pair linkage analysis [ 2 ] [ 6 ] Based on the previous study, the biological behavior of IDDM11is different to HLA region genes so ...
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