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Colchicine is a medication used to prevent and treat gout, [3] [4] to treat familial Mediterranean fever [5] and Behçet's disease, [6] and to reduce the risk of myocardial infarction. [7] The American College of Rheumatology recommends colchicine, nonsteroidal anti-inflammatory drugs (NSAIDs) or steroids in the treatment of gout.
Colchicine poisoning has been compared to arsenic poisoning; symptoms typically start two to five hours after a toxic dose has been ingested but may take up to 24 hours to appear, and include burning in the mouth and throat, fever, vomiting, diarrhea, abdominal pain, and kidney failure. Onset of multiple-system organ failure may occur within 24 ...
Colchicum autumnale, commonly known as autumn crocus, meadow saffron, [3] naked boys [4] or naked ladies, [5] is a toxic autumn-blooming flowering plant that resembles the true crocuses, but is a member of the plant family Colchicaceae, unlike the true crocuses, which belong to the family Iridaceae.
Colchicine is an alternative for those unable to tolerate NSAIDs. [20] At high doses, side effects (primarily gastrointestinal upset) limit its usage. [98] At lower doses, which are still effective, it is well tolerated. [39] [99] [96] [97] Colchicine may interact with other commonly prescribed drugs, such as atorvastatin and erythromycin ...
Colchicine may decrease the frequency of attacks. [2] While rare in the United States and Europe, it is more common in the Middle East and Asia. [2] In Turkey, for example, about 2 per 1,000 are affected. [2] Onset is usually in a person's twenties or forties. [1] [2] The disease was initially described by Turkish dermatologist Hulusi Behçet ...
Colchicine, a drug otherwise mainly used in gout, decreases attack frequency in FMF patients. The exact way in which colchicine suppresses attacks is unclear. While this agent is not without side effects (such as abdominal pain and muscle pains), it may markedly improve the quality of life in patients. The dosage is typically 1–2 mg a day.
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Plants in this genus contain toxic amounts of the alkaloid colchicine which is used pharmaceutically to treat gout and Familial Mediterranean fever. [13] The use of the roots and seeds in traditional medicine is thought to have arisen due to the presence of this drug. [14] Its leaves, corm and seeds are poisonous.