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2. Losartan - Wikipedia

   en.wikipedia.org/wiki/Losartan

   People with type 2 diabetes and kidney disease may experience diarrhea, fatigue, low blood pressure, low blood glucose, elevated potassium, chest pain, or allergic reaction. [3] Losartan should not be taken by people who are diabetic and taking aliskiren. [3] Anemia may occur, due to inhibition of the renin–angiotensin system. [17]

3. Discovery and development of angiotensin receptor blockers

   en.wikipedia.org/wiki/Discovery_and_development...

   A few clinical head-to-head comparisons have been made and candesartan, irbesartan and telmisartan appear to be slightly more effective than losartan in lowering blood pressure. [4] This difference may be related to different strengths of activity at the receptor level, such as duration and strength of receptor binding. [22]

4. Dutasteride - Wikipedia

   en.wikipedia.org/wiki/Dutasteride

   [3] [23] Since dutasteride is an inhibitor of both type 1 and 2 5α-reductases, it could theoretically be a more effective therapy for hirsutism. However, dutasteride is not recommended for this indication due to a lack of supportive clinical evidence and a substantial risk of birth defects in female patients who inadvertently become pregnant ...

5. Angiotensin II receptor blocker - Wikipedia

   en.wikipedia.org/wiki/Angiotensin_II_receptor...

   Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...

6. Antihypertensive - Wikipedia

   en.wikipedia.org/wiki/Antihypertensive

   Chlorthalidone is the thiazide drug that is most strongly supported by the evidence as providing a mortality benefit; in the ALLHAT study, a chlorthalidone dose of 12.5 mg was used, with titration up to 25 mg for those subjects who did not achieve blood pressure control at 12.5 mg. Chlorthalidone has repeatedly been found to have a stronger ...

7. Losartan/hydrochlorothiazide - Wikipedia

   en.wikipedia.org/wiki/Losartan/hydrochlorothiazide

   Losartan/hydrochlorothiazide, sold under the brand name Hyzaar among others, is a fixed-dose combination medication used to treat high blood pressure when losartan is not sufficient. [1] [2] It consists of losartan, an angiotensin II receptor blocker; and hydrochlorothiazide, a thiazide diuretic. [1] [2] It is taken by mouth. [1] [2]

8. Hydrochlorothiazide - Wikipedia

   en.wikipedia.org/wiki/Hydrochlorothiazide

   Hydrochlorothiazide is taken by mouth and may be combined with other blood pressure medications as a single pill to increase effectiveness. [4] Hydrochlorothiazide is a thiazide medication which inhibits reabsorption of sodium and chloride ions from the distal convoluted tubules of the kidneys, causing a natriuresis.

9. Nonsteroidal anti-inflammatory drug - Wikipedia

   en.wikipedia.org/wiki/Nonsteroidal_anti...

   Hypertension (high blood pressure) These agents may also cause kidney impairment, especially in combination with other nephrotoxic agents. Kidney failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin II's vasoconstriction of the efferent arteriole) and a diuretic (which drops plasma ...