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A view of the atomic structure of a single branched strand of glucose units in a glycogen molecule. Glycogen (black granules) in spermatozoa of a flatworm; transmission electron microscopy, scale: 0.3 μm. Glycogen is a multibranched polysaccharide of glucose that serves as a form of energy storage in animals, [2] fungi, and bacteria. [3]
B-type chains, making half of the branches, have two branch points, and all chains have the same length. E. Meléndez-Hevia, R. Meléndez and E. I. Canela (2000) "Glycogen Structure: an Evolutionary View", pp. 319–326 in Technological and Medical Implications of Metabolic Control Analysis (ed. A. Cornish-Bowden and M. L. Cárdenas), Kluwer Academic Publishers, Dordrecht
Glycogenin remains covalently attached to the reducing end of the glycogen molecule. Evidence accumulates that a priming protein may be a fundamental property of polysaccharide synthesis in general; the molecular details of mammalian glycogen biogenesis may serve as a useful model for other systems.
The glycogen phosphorylase monomer is a large protein, composed of 842 amino acids with a mass of 97.434 kDa in muscle cells. While the enzyme can exist as an inactive monomer or tetramer, it is biologically active as a dimer of two identical subunits.
Glycogen branching enzyme is an enzyme that adds branches to the growing glycogen molecule during the synthesis of glycogen, a storage form of glucose. More specifically, during glycogen synthesis, a glucose 1-phosphate molecule reacts with uridine triphosphate (UTP) to become UDP-glucose, an activated form of glucose.
On the other hand, much less is known about the structure of glycogen synthase, the key regulatory enzyme of glycogen synthesis. The crystal structure of glycogen synthase from Agrobacterium tumefaciens, however, has been determined at 2.3 A resolution. [2] In its asymmetric form, glycogen synthase is found as a dimer, whose monomers are ...
Glycogen is analogous to starch, a glucose polymer in plants, and is sometimes referred to as animal starch, [16] having a similar structure to amylopectin but more extensively branched and compact than starch. Glycogen is a polymer of α(1→4) glycosidic bonds linked with α(1→6)-linked branches.
The different functions of glycogen in muscle or liver make the regulation mechanisms of its metabolism differ in each tissue. [7] These mechanisms are based mainly on the differences on structure and on the regulation of the enzymes that catalyze synthesis, glycogen synthase (GS), and degradation, glycogen phosphorylase (GF).