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Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
Kidney toxicity [5] associated with kidney failure; associated with development of cancer, particularly of the urinary tract, known carcinogen [8] [9] Atractylate Atractylis gummifera: Liver damage, [3] nausea, vomiting, epigastric and abdominal pain, diarrhoea, anxiety, headache and convulsions, often followed by coma [10]
Data from Drug Induced Liver Injury Network reported the rates of liver injury due to botanical products has been on the rise from 7% in 2004-2005 to 20% in 2013-2014.
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.. It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, such as carbon tetrachloride, or far more pervasively in the form of ethanol (drinking alcohol).
Paracetamol toxicity is one of the most common causes of poisoning worldwide. [25] In the United States, the United Kingdom, Australia, and New Zealand, paracetamol is the most common cause of drug overdoses. [20] [92] [93] Additionally, in both the United States and the United Kingdom it is the most common cause of acute liver failure. [94] [9]
Liver toxicity is an uncommon but potentially serious side effect, and risk groups e.g. those with already impaired liver function should be monitored closely. That said, the rate of disulfiram-induced hepatitis are estimated to be in between 1 per 25,000 to 1 in 30,000, [13] and rarely the primary cause for treatment cessation.
"Standard preparations of green tea are less likely to cause liver toxicity," Dr. David Kim, MD, hepatologist and gastroenterologist at GI Alliance in Arlington Heights, Illinois, tells Parade ...
Clarithromycin may cause gastrointestinal adverse effects including vomiting, nausea, taste alteration and abdominal pain. [39] This medication can also cause liver toxicity. [39] Symptoms of liver damage include anorexia, dark urine, jaundice, tender abdomen and pruritus. [39] To assess the liver function, ALT/AST should be closely monitored. [39]