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Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. [1] They are a bio-marker implicated in aging and the development, or worsening, of many degenerative diseases , such as diabetes , atherosclerosis , chronic kidney disease , and Alzheimer's disease .
Glycation is the non-enzymatic process responsible for many (e.g. micro and macrovascular) complications in diabetes mellitus and is implicated in some diseases and in aging. [2] [3] [4] Glycation end products are believed to play a causative role in the vascular complications of diabetes mellitus. [5]
The polyol metabolic pathway. [6]Cells use glucose for energy.This normally occurs by phosphorylation from the enzyme hexokinase. However, if large amounts of glucose are present (as in diabetes mellitus), hexokinase becomes saturated and the excess glucose enters the polyol pathway when aldose reductase reduces it to sorbitol.
Luckily, type 2 diabetes can be managed (and even reversed) with a nutrient-dense diet that focuses on whole foods. Balancing your plate with lean protein, healthy fat, fiber, and complex carbs ...
Eating too much sugar is associated with many of the leading causes of death in the U.S., including heart disease, certain cancers, and type 2 diabetes, among others. ... A high-glycemic diet (one ...
Some studies suggest that even though they’re sugar-free, diet sodas may still come with an increased risk of obesity, type 2 diabetes, stroke, dementia, and heart disease.
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