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The parameters of the dose response curve reflect measures of potency (such as EC50, IC50, ED50, etc.) and measures of efficacy (such as tissue, cell or population response). A commonly used dose–response curve is the EC 50 curve, the half maximal effective concentration, where the EC 50 point is defined as the inflection point of the curve.
A quantal dose response curve shows the percentage of subjects where a response is noted in an all-or-none manner (y axis) over the dose of the drug (x axis). For competition binding assays and functional antagonist assays IC 50 is the most common summary measure of the dose-response curve.
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Estimation of the complete dose-response curve without any additional assumptions is usually done via linear interpolation between the point estimates. [3] Software for computing isotone (monotonic) regression has been developed for R, [4] [5] [6] Stata, and Python. [7]
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This page was last edited on 16 September 2014, at 22:47 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Thermophoresis, the movement of the molecule in the temperature gradient, depends on three parameters that typically change upon interaction. Thus, the overall MST signal is plotted against the ligand concentration to obtain a dose-response curve, from which the binding affinity can be deduced.
A response surface is a three dimensional graph with concentrations of individual components in toxic units on the x and y axis and the response variable on the z axis. This three dimensional representation of the organisms response to the two chemical stressors can be used to predict the toxicity of any combination of the components based on ...