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RUNX2 is a key transcription factor associated with osteoblast differentiation. It has also been suggested that Runx2 plays a cell proliferation regulatory role in cell cycle entry and exit in osteoblasts, as well as endothelial cells. Runx2 suppresses pre-osteoblast proliferation by affecting cell cycle progression in the G1 phase. [6]
The PIP gene is amplified in some breast cancer lines accounting for some of its overexpression, however additional mechanisms are needed to completely explain its overexpression. [21] In T47D breast cancer cells, androgen receptor and RUNX2 interact to synergistically enhance PIP expression. [22]
This overexpression leads to downregulation of the transcription factor PITX3. [13] miR-133a is down regulated in diabetic cardiomyopathy. [14] miR-133 suppresses Prdm16 expression in skeletal muscle stem cells (satellite cells), which controls myogenic vs. brown adipogenic lineage determination in these cells. [15]
Furthermore, Ito et al. purified Runx2, the homolog of Runx1. [17] Purified transcription factors consisted of two subunits, a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding subunit called core binding factor β (CBFβ); the binding affinity of RUNX1 and RUNX2 was significantly increased by association with CBFβ. [17] [18] [19]
Transcription factor Sp7, also called Osterix (Osx), is a protein that in humans is encoded by the SP7 gene. [5] It is a member of the Sp family of zinc-finger transcription factors [5] It is highly conserved among bone-forming vertebrate species [6] [7] It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of mesenchymal precursor cells into osteoblasts and ...
13875 Ensembl ENSG00000105722 ENSMUSG00000040857 UniProt P50548 P70459 RefSeq (mRNA) NM_001301035 NM_001308402 NM_001312656 NM_006494 NM_010155 RefSeq (protein) NP_001287964 NP_001295331 NP_001299585 NP_006485 NP_034285 Location (UCSC) Chr 19: 42.25 – 42.26 Mb Chr 7: 25.24 – 25.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ETS domain-containing transcription factor ERF is a ...
6909 21385 Ensembl ENSG00000121068 ENSMUSG00000000093 UniProt Q13207 Q60707 RefSeq (mRNA) NM_005994 NM_009324 RefSeq (protein) NP_005985 NP_033350 Location (UCSC) Chr 17: 61.4 – 61.41 Mb Chr 11: 85.72 – 85.73 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans ...
In 2011 doubt was cast over the tumor suppressor function of Runx3 originated from the earlier publication by Li and co-workers. [12] On the basis of the original study by Li and co-workers (2002), the majority of later literature citing Li and co-workers (2002) assumed that RUNX3 was expressed in the normal gut epithelium and that it is therefore likely to act as a tumor suppressor in the ...