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Tight control of miRNA is vital to normal functioning cells. If dysregulated, miRNAs can often be linked to human diseases such as cancer. By focusing on the miRNA biogenesis, Dr. Kim's lab has made major contributions to the understanding of miRNAs are created and processed in animal cells.
miRNA biogenesis in plants differs from animal biogenesis mainly in the steps of nuclear processing and export. Instead of being cleaved by two different enzymes, once inside and once outside the nucleus, both cleavages of the plant miRNA are performed by a Dicer homolog, called Dicer-like1 (DL1). DL1 is expressed only in the nucleus of plant ...
In the past it had always been said that the same miRNA precursor generates the same miRNA sequences. However, the advent of deep sequencing has now allowed researchers to detect a huge variability in miRNA biogenesis, meaning that from the same miRNA precursor many different sequences can be generated potentially have different targets, [ 3 ...
These two proteins homeostatically control miRNA biogenesis by an auto-feedback loop. [16] A 2nt 3' overhang is generated by Drosha in the nucleus recognized by Dicer in the cytoplasm, which couples the upstream and downstream processing events. Pre-miRNA is then further processed by the RNase Dicer into mature miRNAs in the cell cytoplasm.
An Argonaute protein known as AGO4 interacts with the small RNAs that define heterochromatic sequences. A histone methyl transferase (HMT), H3K9, methylates histone H3 and recruits chromodomain proteins to the methylation sites. DNA methylation maintains the silencing of genes as the heterochromatin sequences can be established or spread.
Scammers can use your email to target you directly. And, unfortunately, plenty of email phishing scams today are more sophisticated than the older varieties that would directly ask for your ...
While the science and technology necessary to create mirror bacteria in a laboratory is a decade or more away, the scientists argued that the possibly lethal risks posed by this new field of ...
The Let-7 microRNA precursor gives rise to let-7, a microRNA (miRNA) involved in control of stem-cell division and differentiation. [1] let-7, short for "lethal-7", was discovered along with the miRNA lin-4 in a study of developmental timing in C. elegans, [2] making these miRNAs the first ever discovered.