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Biosynthesis: The enzyme 3-dehydroquinate dehydratase uses 3-dehydroquinate to produce 3-dehydroshikimate and H 2 O. 3-Dehydroshikimate is then reduced to shikimic acid by the enzyme shikimate dehydrogenase, which uses nicotinamide adenine dinucleotide phosphate (NADPH) as a cofactor. Biosynthesis of shikimic acid from 3-dehydroquinate
3-dehydroshikimate dehydratase (EC 4.2.1.118) is an enzyme with systematic name 3-dehydroshikimate hydro-lyase. [1] [2] This enzyme catalyses the following chemical reaction. 3-dehydro-shikimate 3,4-dihydroxybenzoate + H 2 O. This enzyme catalyses an early step in the biosynthesis of petrobactin.
The enzyme 3-dehydroquinate dehydratase (EC 4.2.1.10) catalyzes the chemical reaction. 3-dehydroquinate 3-dehydroshikimate + H 2 O. This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis
Shikimate dehydrogenase is an enzyme that catalyzes one step of the shikimate pathway.This pathway is found in bacteria, plants, fungi, algae, and parasites and is responsible for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, and tryptophan) from the metabolism of carbohydrates.
This page was last edited on 17 December 2012, at 11:51 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Shikimic acid can also be extracted from the seeds of the sweetgum (Liquidambar styraciflua) fruit, [2] which is abundant in North America, in yields of around 1.5%. For example, 4 kg (8.8 lb) of sweetgum seeds is needed for fourteen packages of Tamiflu. By comparison, star anise has been reported to yield 3% to 7% shikimic acid.
(2) shikimate + NAD(P) + 3-dehydroshikimate + NAD(P)H + H + This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25 , shikimate dehydrogenase, in that it can use both quinate and shikimate as substrate, and either NAD + or NADP + as acceptor.
The systematic name of this enzyme class is 3-deoxy-D-arabino-hept-2-ulosonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming). Other names in common use include 5-dehydroquinate synthase, 5-dehydroquinic acid synthetase, dehydroquinate synthase, 3-dehydroquinate synthetase, 3-deoxy-arabino-heptulosonate-7-phosphate phosphate ...
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