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  2. Hartnup disease - Wikipedia

    en.wikipedia.org/wiki/Hartnup_disease

    Hartnup disease (also known as "pellagra-like dermatosis" [1] and "Hartnup disorder" [2]) is an autosomal recessive [3] metabolic disorder affecting the absorption of nonpolar amino acids (particularly tryptophan that can be, in turn, converted into serotonin, melatonin, and niacin).

  3. Kynurenine pathway - Wikipedia

    en.wikipedia.org/wiki/Kynurenine_pathway

    Also known as kynureninase deficiency, this extremely rare inherited disorder is caused by the defective enzyme kynureninase which leads to a block in the pathway from tryptophan to niacin (nicotinic acid). As a result, tryptophan is no longer a source of niacin, hence leading to pellagra (niacin deficiency).

  4. Niacin - Wikipedia

    en.wikipedia.org/wiki/Niacin

    A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [7]

  5. Excess amounts of this B vitamin linked to higher heart ...

    www.aol.com/excess-amounts-b-vitamin-linked...

    About 1 in 4 Americans have too much niacin in their body from eating meats and nuts, ... But even though niacin deficiency is a rarity in the U.S., some people do take it as a dietary supplement ...

  6. Nutrition and cognition - Wikipedia

    en.wikipedia.org/wiki/Nutrition_and_cognition

    Vitamin B 3, also known as niacin, includes both nicotinamide as well as nicotinic acid, both of which function in many biological oxidization and reduction reactions within the body. Niacin is involved in the synthesis of fatty acids and cholesterol, known mediators of brain biochemistry, and in effect, of cognitive function. [21]

  7. Do NAD supplements actually have benefits? Doctors ... - AOL

    www.aol.com/nad-supplements-actually-benefits...

    The body also converts niacin and the amino acid tryptophan into NAD, says Martens — these are both found in some foods and available as supplements, but may not be as effective.

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