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  2. Sacubitril/valsartan - Wikipedia

    en.wikipedia.org/wiki/Sacubitril/valsartan

    Sacubitril/valsartan, sold under the brand name Entresto among others, is a fixed-dose combination medication for use in heart failure. It consists of the neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan .

  3. Sacubitril - Wikipedia

    en.wikipedia.org/wiki/Sacubitril

    Sacubitril is a prodrug that is activated to sacubitrilat (LBQ657) by de-ethylation via esterases. [2] Sacubitrilat inhibits the enzyme neprilysin, [3] which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure–lowering peptides that work mainly by reducing blood volume. [4]

  4. Hypertensive encephalopathy - Wikipedia

    en.wikipedia.org/wiki/Hypertensive_encephalopathy

    In hypertensive encephalopathy, generally the blood pressure is greater than 200/130 mmHg. [1] Occasionally it can occur at a BP as low as 160/100 mmHg. [4] This can occur in kidney failure, those who rapidly stop blood pressure medication, pheochromocytoma, and people on a monoamine oxidase inhibitor (MAOI) who eat foods with tyramine. [2]

  5. Antihypertensive - Wikipedia

    en.wikipedia.org/wiki/Antihypertensive

    Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke, heart failure, kidney failure and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21%, and can reduce the likelihood of dementia ...

  6. Hypertensive kidney disease - Wikipedia

    en.wikipedia.org/wiki/Hypertensive_kidney_disease

    "Hypertensive" refers to high blood pressure and "nephropathy" means damage to the kidney; hence this condition is where chronic high blood pressure causes damages to kidney tissue; this includes the small blood vessels, glomeruli, kidney tubules and interstitial tissues. The tissue hardens and thickens which is known as nephrosclerosis. [2]

  7. Complications of hypertension - Wikipedia

    en.wikipedia.org/wiki/Complications_of_hypertension

    The high blood pressure is gradual at early stages and may take at least 10–15 years to fully develop. Besides diabetes, other factors that may also increase high blood pressure include obesity, insulin resistance and high cholesterol levels. In general, fewer than 25 percent of diabetics have good control of their blood pressure. The ...

  8. Hypertension - Wikipedia

    en.wikipedia.org/wiki/Hypertension

    Hypertension, also known as high blood pressure, is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. [11] High blood pressure usually does not cause symptoms itself. [1]

  9. Management of hypertension - Wikipedia

    en.wikipedia.org/wiki/Management_of_hypertension

    A review in 2012 found that a diet high in potassium lowers blood pressure in those with high blood pressure and may improve outcomes in those with normal kidney function, [20] while a 2006 review found evidence to be inconsistent; additionally, the review found no significant reduction in blood pressure overall for people with high blood ...

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