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[4] [3] It has a black box warning about the risk of serious dehydration in children in the US; the most common adverse effects in others include diarrhea. [4] It is an oligopeptide agonist of guanylate cyclase 2C and remains in the GI tract after it is taken by mouth. It was approved in the US and the European Union in 2012. [7]
Piperacillin with tazobactam is administered through an intravenous (IV) method, where it is infused into the bloodstream over a period of 30 minutes to 4 hours so that the medication is delivered slowly and steadily.
The binding of ceftolozane to human plasma proteins is approximately 16% to 21%, while the binding of tazobactam is approximately 30%. The mean steady-state volume of distribution in healthy adult males after a single 1.5 g IV dose is 13.5 L for ceftolozane and 18.2 L for tazobactam, which is similar to extracellular fluid volume.
Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. It is commonly used as its sodium salt, tazobactam sodium.
Lubiprostone, sold under the brand name Amitiza among others, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. The drug is owned by Mallinckrodt and is marketed by Takeda Pharmaceutical Company.
Senna glycoside, also known as sennoside or senna, is a medication used to treat constipation and empty the large intestine before surgery. [1] [5] The medication is taken by mouth or via the rectum. [1] [6] It typically begins working in around 30 minutes when given by rectum and within twelve hours when given by mouth. [3]
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Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning, [2] including both short-term and long-term lead poisoning. [3] Sodium calcium edetate came into medical use in the United States in 1953. [3]
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