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The trifluoromethyl cation is a molecular cation with a formula of CF + 3. It is a carbocation due to its positively charged carbon atom. It is part of the family of carbenium ions, with three fluorine atoms as substituents in place of its hydrogen atoms. [1]
It has been suggested that Trifluoromethyl cation be merged into this article. ( Discuss ) Proposed since November 2024. Trifluoromethylation in organic chemistry describes any organic reaction that introduces a trifluoromethyl group in an organic compound.
This glossary of biology terms is a list of definitions of fundamental terms and concepts used in biology, the study of life and of living organisms.It is intended as introductory material for novices; for more specific and technical definitions from sub-disciplines and related fields, see Glossary of cell biology, Glossary of genetics, Glossary of evolutionary biology, Glossary of ecology ...
Trifluoromethyl group covalently bonded to an R group. The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H ...
A triflate group is an excellent leaving group used in certain organic reactions such as nucleophilic substitution, Suzuki couplings and Heck reactions.Since alkyl triflates are extremely reactive in S N 2 reactions, they must be stored in conditions free of nucleophiles (such as water).
Many organofluorine compounds are generated from reagents that deliver perfluoroalkyl and perfluoroaryl groups. (Trifluoromethyl)trimethylsilane, CF 3 Si(CH 3) 3, is used as a source of the trifluoromethyl group, for example. [24] Among the available fluorinated building blocks are CF 3 X (X = Br, I), C 6 F 5 Br, and C 3 F 7 I.
The [BAr F 4] − anion with four fluorinated aryl groups distributed tetrahedrally about a central boron atom. Tetrakis[3,5-bis(trifluoromethyl)phenyl]borate is an anion with chemical formula [{3,5-(CF 3) 2 C 6 H 3} 4 B] −, which is commonly abbreviated as [BAr F 4] −, indicating the presence of fluorinated aryl (Ar F) groups.
For example, a chloride -Cl group may often be replaced by a trifluoromethyl -CF 3 group or by a cyano -C≡N group. Depending on the particular molecule used, the substitution may result in little change in activity, or either increased or decreased affinity or efficacy - depending on what factors are important for ligand binding to the target ...