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The trifluoromethyl cation is a molecular cation with a formula of CF + 3. It is a carbocation due to its positively charged carbon atom.
It has been suggested that Trifluoromethyl cation be merged into this article. ( Discuss ) Proposed since November 2024. Trifluoromethylation in organic chemistry describes any organic reaction that introduces a trifluoromethyl group in an organic compound.
Trifluoromethyl group covalently bonded to an R group. The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H ...
For example, n-butyl triflate can be written as CH 3 CH 2 CH 2 CH 2 OTf. The corresponding triflate anion , CF 3 SO − 3 , is an extremely stable polyatomic ion ; this comes from the fact that triflic acid ( CF 3 SO 3 H ) is a superacid ; i.e. it is more acidic than pure sulfuric acid , already one of the strongest acids known.
The methylphenyl group occupies a hydrophobic pocket behind I315, the ethynyl linkage forms favorable van der Waals interactions with the amino acid and the trifluoromethyl group binds to a pocket induced by the inactive conformation kinase. Also in the conformation of the kinase that ponatinib rests in, additional favorable van der Waals ...
For example, protonation of methanol gives an electrophilic methylating reagent that reacts by the S N 2 pathway: CH 3 OH + H + → [CH 3 OH 2] + Similarly, methyl iodide and methyl triflate are viewed as the equivalent of the methyl cation because they readily undergo S N 2 reactions by weak nucleophiles. The methyl cation has been detected in ...
Trifluoromethoxy group. The trifluoromethoxy group is the chemical group –O– CF 3.It can be seen as a methoxy group –O– CH 3 whose hydrogen atoms are replaced by fluorine atoms; or as a trifluoromethyl group attached to the rest of the molecule by a bridging oxygen atom; either leads to viable syntheses. [1]
Fluoroform is weakly acidic with a pK a = 25–28 and quite inert. Attempted deprotonation results in defluorination to generate F − and difluorocarbene (CF 2).Some organocopper and organocadmium compounds have been developed as trifluoromethylation reagents.