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Ménétrier disease is a rare, acquired, premalignant disease of the stomach characterized by massive gastric folds, excessive mucus production with resultant protein loss, and little or no acid production (achlorhydria). The disorder is associated with excessive secretion of transforming growth factor alpha (TGF-α). [1]
The gastric folds (or gastric rugae) are coiled sections of tissue that exist in the mucosal and submucosal layers of the stomach. [1] They provide elasticity by allowing the stomach to expand when a bolus enters it. These folds stretch outward through the action of mechanoreceptors, which respond to the increase in pressure. [2]
Those with autoimmune atrophic gastritis (Type A gastritis) are statistically more likely to develop gastric carcinoma (a form of stomach cancer), Hashimoto's thyroiditis, and achlorhydria. Type A gastritis primarily affects the fundus (body) of the stomach and is more common with pernicious anemia . [ 1 ]
What Causes Stomach Bloating? Stomach bloating happens when the gastrointestinal (GI) tract fills with air or gas. Occasional bloating is often caused by types of food and drink, ...
Studies have not found that soy and vegetables cause bloating, but dry foods that contain a fatty oil among the first four ingredients have been shown to have a 2.4-fold increase in bloat (2).
The first step in diagnosis is to determine the etiology of abdominal distension. After making a differential diagnosis of abdominal distension, it is important to take a careful medical history. [9] Here are the most common causes of abdominal distension classified as an underlying cause and as a secondary disease. As an underlying disease cause:
Gastric distention is the enlargement of the stomach, and can be due to a number of causes. [citation needed]Physiologic (normal) gastric distension occurs when eating. . Distension of the upper stomach stimulates the secretion of stomach acid, while distension of the lower stomach stimulates gastrin secret
Gastric outlet obstruction (GOO) is a medical condition where there is an obstruction at the level of the pylorus, which is the outlet of the stomach.Individuals with gastric outlet obstruction will often have recurrent vomiting of food that has accumulated in the stomach, but which cannot pass into the small intestine due to the obstruction.