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A 2012 study suggests that players in the National Football League are three times more likely to die from neurodegenerative diseases, including Alzheimer's and Parkinson's diseases, than the general US population. [43] A 2018 study found 56% increase in risk of Parkinson's disease among US military veterans suffered traumatic brain injury. [42]
A brain tissue with Lewy bodies. The first major proposed cause of neuronal death in Parkinson's disease is the bundling, or oligomerization, of proteins.The protein alpha-synuclein has increased presence in the brains of Parkinson's Disease patients and, as α-synuclein is insoluble, it aggregates to form Lewy bodies (shown to left) in neurons.
Although genetics is the sole factor in a minority of cases, most cases of Parkinson's are likely a result of gene-environment interactions: concordance studies with twins have found Parkinson's heritability to be just 30%. [234] The influence of multiple genetic and environmental factors complicates epidemiological efforts. [238]
Parkinsonism is a clinical syndrome characterized by the four motor symptoms found in Parkinson's disease: tremor, bradykinesia (slowed movements), rigidity, and postural instability. [1] [2] Parkinsonism gait problems can lead to falls and serious physical injuries. Other common symptoms include:
This is an incomplete list, which may never be able to satisfy certain standards for completion.. There are many conditions of or affecting the human circulatory system — the biological system that includes the pumping and channeling of blood to and from the body and lungs with heart, blood and blood vessels.
Parkinson’s disease was correlated with genes linked to intracranial and subcortical brain volumes. ADHD, insomnia , and neuroticism were negatively correlated with genes controlling ...
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