Search results
Results from the WOW.Com Content Network
4,7-Dichloroquinoline was first reported in a patent filed by IG Farben in 1937. [2] However, its synthesis was not investigated in detail until chloroquine was developed as an antimalarial drug. [ 3 ] : 130–132 A route to the intermediate starting from 3-chloroaniline was developed by chemists at Winthrop Chemical Co .
[1] [4] Chloroquine is a member of the drug class 4-aminoquinoline. [1] As an antimalarial, it works against the asexual form of the malaria parasite in the stage of its life cycle within the red blood cell. [1] How it works in rheumatoid arthritis and lupus erythematosus is unclear. [1] Chloroquine was discovered in 1934 by Hans Andersag.
The ester group is hydrolysed by sodium hydroxide to the carboxylic acid and decarboxylation again by application of heat to 4-hydroxyquinoline. Gould–Jacobs reaction. Extension of the Gould-Jacobs approach can prepare unsubstituted parent heterocycles with fused pyridine ring of Skraup type (see Skraup reaction). [1] Further reading: [4] [5] [6]
[3] [4] Although all risk cannot be excluded, it remains a treatment for rheumatic disease during pregnancy. [5] Hydroxychloroquine is in the antimalarial and 4-aminoquinoline families of medication. [3] Hydroxychloroquine was approved for medical use in the United States in 1955. [3] It is on the World Health Organization's List of Essential ...
This category has the following 7 subcategories, out of 7 total. D. Dibenzoquinolines (8 P) P. Pyridazinoquinolines (1 P) Q. ... 4,7-Dichloroquinoline ...
Sodium hydroxide, also known as lye and caustic soda, [1] [2] is an inorganic compound with the formula NaOH. It is a white solid ionic compound consisting of sodium cations Na + and hydroxide anions OH −. Sodium hydroxide is a highly corrosive base and alkali that decomposes lipids and proteins at ambient temperatures and may cause severe ...
WASHINGTON (Reuters) -U.S. President-elect Donald Trump on Saturday named his social media platform CEO Devin Nunes to lead an intelligence advisory panel and said his former intelligence chief ...
Preparation of 4-chloroquinazoline and its tosylhydrazide. Tosylhydrazides can be installed by nucleophilic attack and later removed by base. It thus provides a way to convert C-Cl to C-H. [3] With ketones and aldehydes, it condenses to give the hydrazones: CH 3 C 6 H 4 SO 2 NHNH 2 + R 2 C=O → CH 3 C 6 H 4 SO 2 NHN=CR 2 + H 2 O