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Sterol+Regulatory+Element+Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) The Brown and Goldstein Lab Archived 2009-05-26 at the Wayback Machine. Cholesterol Synthesis Archived 2017-07-04 at the Wayback Machine - has some good regulatory details; Protein Data Base (PDB), Sterol Regulatory Element ...
Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene. [5] [6] This gene is located within the Smith–Magenis syndrome region on chromosome 17.
The main regulatory mechanism is the sensing of intracellular cholesterol in the endoplasmic reticulum by the protein SREBP (sterol regulatory element-binding protein 1 and 2). [45] In the presence of cholesterol, SREBP is bound to two other proteins: SCAP (SREBP cleavage-activating protein) and INSIG-1.
SCAP is a regulatory protein that is required for the proteolytic cleavage of the sterol regulatory element-binding protein . SCAP is an integral membrane protein located in the endoplasmic reticulum (ER). One of the cytosolic regions of SCAP contains a hexapeptide amino acid sequence, MELADL, that functions to detect cellular cholesterol. When ...
Several key enzymes can be activated through DNA transcriptional regulation on activation of SREBP (sterol regulatory element-binding protein-1 and -2). This intracellular sensor detects low cholesterol levels and stimulates endogenous production by the HMG-CoA reductase pathway, as well as increasing lipoprotein uptake by up-regulating the LDL ...
SREBP cleavage-activating protein (SCAP), which regulates transcription of genes with sterol response elements by proteolytically activating sterol regulatory element-binding proteins (SREBPs). This was the second SSD-containing protein to be discovered. 7-dehydrocholesterol reductase (7DHCR), involved in the last step of cholesterol biosynthesis.
The gene for the mitochondrial form of the enzyme has three sterol regulatory elements in the 5' flanking region. [4] These elements are responsible for decreased transcription of the message responsible for enzyme synthesis when dietary cholesterol is high in animals: the same is observed for 3-hydroxy-3-methylglutaryl-CoA and the low density ...
Sterol carrier proteins (also known as nonspecific lipid transfer proteins) is a family of proteins that transfer steroids and probably also phospholipids and gangliosides between cellular membranes. These proteins are different from plant nonspecific lipid transfer proteins but structurally similar to small proteins of unknown function from ...